Aloe Vera gel extract and sunlight mediated synthesis of silver nanoparticles with highly effective antibacterial and anticancer activity

In this study, a single-step method for green synthesis of silver nanoparticles usingAloe Vera gel extract and sunlight was investigated. The Aloe Vera gel extractis composed of pectins, lignin, and hemicellulose, which can be used in thereduction of silver ions to produce colloidal silver nanoparticles (AgNPs-AV). Thepreliminary preparation of silver nanoparticles was observed by an immediatecolor change to brown. The prepared silver nanoparticles were characterizedby transmission electron microscopy, Fourier transform infrared spectroscopy,dynamic light scattering, and zeta potential measurements. Additionally, thecytotoxicity and antimicrobial activity of AgNPs-AV was tested. Results indicatedthe formation of stable spherical 90±40nm with a strong absorption peak appearsbetween 400 and 500 nm. 28.7 ±0.781% of breast cancer cells survived afterincubation with AgNPs-AV invitro for 72 hrs. In addition to AgNPs-AV inhibitedthe growth of the most important human skin pathogens (candida albicans,Pseudomonas aeruginosa and Staphylococcus aureus). The largest inhibitionzone was observed for candida albicans. This method for synthesis is very fast,produces spherical colloidal silver nanoparticles having an excellent antioxidantactivity, high anticancer therapeutic index and very promising antibacterialactivity. This greenly synthesized nano-formulation has a great potential to beexplored in many different aspects.